Dra. Gloria Hernández Alcántara

Académicos del Departamento

Facultad de Medicina, UNAM

ghernandez@bq.unam.mx

ghalcantara@facmed.unam.mx

galcantara72@yahoo.com.mx

Laboratorio de péptidos y proteínas, segundo piso, Torre de investigación. Facultad de Medicina, UNAM

Tel. +52 (55) 56232133

Mi interés se centra en la evolución, estructura y función de enzimas que participanen el metabolismo energético de las gammaproteobacterias del género Vibrio, especialmente en las enzimas que participan en la vía glucolítica y que se encuentran duplicadas en su genoma.

Experiencia Profesional

Líneas de Investigación

Análisis de la estructura y función de las tres isoformas de piruvato cinasa presentes en Vibrios.
Estudio del proceso de oligomerización y su importancia en la función y estructura de la isofoforma II de piruvato cinasa de Vibrio cholerae
La isoforma M2 de piruvato cinas (PKM2) como diana en cáncer hemato-oncológico

Trayectoria profesional

Investigador Titular “A” TC, SNI I, PRIDE C Facultad de Medicina, UNAM (desde 16 de mayo de 2012)

Formación académica

Doctorado en Ciencias Bioquímicas. Del 2000 al 2003. Obtención del grado 9 de mayo del 2003. Cédula profesional: 4336202. Institución:Facultad de Química, UNAM.
Maestría en Ciencias Bioqímicas. De 1997 a 1999. Obtención del grado: 10 de junio del 2000. Cédula profesional: 3309012.Institución: Facultad de Química, UNAM.
Licenciatura en Biología. De 1992 a 1995. Obtención del grado 26 de enero de 1996. Cédula profesional: 3152830Institución: Universidad Veracruzana

Alumnos

Mariana Durán Gutierrez: Biología

Tesis de Licenciatura

Michelle Cristal Cortes Madrid

Tesis de Licenciatura

Emilio Sarmiento Gallegos

Tesis de Licenciatura

Karla Mendoza Leal. Biología

Tesis de Licenciatura

Ireric De la Rosa Ruíz

Tesis de Licenciatura

Mariana Ery Tanaka Kerrigan

Tesis de Licenciatura

Publicaciones

Flores-López LA, De la Mora-De la Mora I, Malagón-Reyes CM, García-Torres I, Martínez-Pérez Y, López-Herrera G, Hernández-Alcántara G, León-Avila G, López-Velázquez G, Olaya-Vargas A, Gómez-Manzo S and Enríquez-Flores S. Selective Inhibition of Deamidated Triosephosphate Isomerase by Disulfiram, Curcumin, and Sodium Dichloroacetate: Synergistic Therapeutic Strategies for T-Cell Acute Lymphoblastic Leukemia in Jurkat Cells. (2024) Biomolecules. 14, Pubmed Biomolecules PMC Article

de la Mora-de la Mora I, García-Torres I, Flores-López LA, López-Velázquez G, Hernández-Alcántara G, Gómez-Manzo S and Enríquez-Flores S. Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations. (2024) Molecules. 29, Pubmed Molecules PMC Article

Enríquez-Flores S, De la Mora-De la Mora JI, Flores-López LA, Cabrera N, Fernández-Lainez C, Hernández-Alcántara G, Guerrero-Beltrán CE, López-Velázquez G and García-Torres I. Improved yield, stability, and cleavage reaction of a novel tobacco etch virus protease mutant. (2022) Appl Microbiol Biotechnol. 106, 1475-1492 Pubmed Appl Microbiol Biotechnol

Ramírez-Silva L, Hernández-Alcántara G, Guerrero-Mendiola C, González-Andrade M, Rodríguez-Romero A, Rodríguez-Hernández A, Lugo-Munguía A, Gómez-Coronado PA, Rodríguez-Méndez C and Vega-Segura A. The K-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms. (2022) Int J Mol Sci. 23, Pubmed Int J Mol Sci PMC Article

Alba-Martínez Z, Ramírez-Silva L and Hernández-Alcántara G. Exploring the differences between the three pyruvate kinase isozymes from Vibrio cholerae in a heterologous expression system. (2018) BMC Res Notes. 11, 527 Pubmed BMC Res Notes PMC Article

García-Torres I, De la Mora-De la Mora I, Hernández-Alcántara G, Molina-Ortiz D, Caballero-Salazar S, Olivos-García A, Nava G, López-Velázquez G and Enríquez-Flores S. First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target. (2018) Sci Rep. 8, 8591 Pubmed Sci Rep PMC Article

Hernández Alcantara G, Jiménez Cruz A and Bacardí Gascón M. [EFFECT OF LOW CARBOHYDRATE DIETS ON WEIGHT LOSS AND GLYCOSILATED HEMOGLOBIN IN PEOPLE WITH TYPE 2 DIABETES: SYSTEMATIC REVIEW]. (2015) Nutr Hosp. 32, 1960-6 Pubmed Nutr Hosp

Reyes-Vivas H, de la Mora-de la Mora I, Castillo-Villanueva A, Yépez-Mulia L, Hernández-Alcántara G, Figueroa-Salazar R, García-Torres I, Gómez-Manzo S, Méndez ST, Vanoye-Carlo A, Marcial-Quino J, Torres-Arroyo A, Oria-Hernández J, Gutiérrez-Castrellón P, Enríquez-Flores S and López-Velázquez G. Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia. (2014) Antimicrob Agents Chemother. 58, 7072-82 Pubmed Antimicrob Agents Chemother PMC Article

Gómez-Manzo S, Terrón-Hernández J, De la Mora-De la Mora I, González-Valdez A, Marcial-Quino J, García-Torres I, Vanoye-Carlo A, López-Velázquez G, Hernández-Alcántara G, Oria-Hernández J, Reyes-Vivas H and Enríquez-Flores S. The stability of G6PD is affected by mutations with different clinical phenotypes. (2014) Int J Mol Sci. 15, 21179-201 Pubmed Int J Mol Sci PMC Article

Enríquez-Flores S, Rodríguez-Romero A, Hernández-Alcántara G, Oria-Hernández J, Gutiérrez-Castrellón P, Pérez-Hernández G, de la Mora-de la Mora I, Castillo-Villanueva A, García-Torres I, Méndez ST, Gómez-Manzo S, Torres-Arroyo A, López-Velázquez G and Reyes-Vivas H. Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design. (2011) Proteins. 79, 2711-24 Pubmed Proteins

Hernández-Alcántara G, Rodríguez-Romero A, Reyes-Vivas H, Peon J, Cabrera N, Ortiz C, Enríquez-Flores S, De la Mora-De la Mora I and López-Velázquez G. Unraveling the mechanisms of tryptophan fluorescence quenching in the triosephosphate isomerase from Giardia lamblia. (2008) Biochim Biophys Acta. 1784, 1493-500 Pubmed Biochim Biophys Acta

Cabrera N, Hernández-Alcántara G, Mendoza-Hernández G, Gómez-Puyou A and Perez-Montfort R. Key residues of loop 3 in the interaction with the interface residue at position 14 in triosephosphate isomerase from Trypanosoma brucei. (2008) Biochemistry. 47, 3499-506 Pubmed Biochemistry

Enriquez-Flores S, Rodriguez-Romero A, Hernandez-Alcantara G, De la Mora-De la Mora I, Gutierrez-Castrellon P, Carvajal K, Lopez-Velazquez G and Reyes-Vivas H. Species-specific inhibition of Giardia lamblia triosephosphate isomerase by localized perturbation of the homodimer. (2008) Mol Biochem Parasitol. 157, 179-86 Pubmed Mol Biochem Parasitol

Zomosa-Signoret V, Aguirre-López B, Hernández-Alcántara G, Pérez-Montfort R, de Gómez-Puyou MT and Gómez-Puyou A. Crosstalk between the subunits of the homodimeric enzyme triosephosphate isomerase. (2007) Proteins. 67, 75-83 Pubmed Proteins

Reyes-Vivas H, Diaz A, Peon J, Mendoza-Hernandez G, Hernandez-Alcantara G, De la Mora-De la Mora I, Enriquez-Flores S, Dominguez-Ramirez L and Lopez-Velazquez G. Disulfide bridges in the mesophilic triosephosphate isomerase from Giardia lamblia are related to oligomerization and activity. (2007) J Mol Biol. 365, 752-63 Pubmed J Mol Biol

López-Velázquez G, Molina-Ortiz D, Cabrera N, Hernández-Alcántara G, Peon-Peralta J, Yépez-Mulia L, Pérez-Montfort R and Reyes-Vivas H. An unusual triosephosphate isomerase from the early divergent eukaryote Giardia lamblia. (2004) Proteins. 55, 824-34 Pubmed Proteins

Zomosa-Signoret V, Hernández-Alcántara G, Reyes-Vivas H, Martínez-Martínez E, Garza-Ramos G, Pérez-Montfort R, Tuena De Gómez-Puyou M and Gómez-Puyou A. Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers. (2003) Biochemistry. 42, 3311-8 Pubmed Biochemistry

Hernández-Alcántara G, Garza-Ramos G, Hernández GM, Gómez-Puyou A and Pérez-Montfort R. Catalysis and stability of triosephosphate isomerase from Trypanosoma brucei with different residues at position 14 of the dimer interface. Characterization of a catalytically competent monomeric enzyme. (2002) Biochemistry. 41, 4230-8 Pubmed Biochemistry

Reyes-Vivas H, Hernández-Alcantara G, López-Velazquez G, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT and Gómez-Puyou A. Factors that control the reactivity of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi. (2001) Biochemistry. 40, 3134-40 Pubmed Biochemistry

De la Vega-Ruíz G, Domínguez-Ramírez L, Riveros-Rosas H, Guerrero-Mendiola C, Torres-Larios A, Hernández-Alcántara G, García-Trejo JJ and Ramírez-Silva L. Correction: New Insights on the Mechanism of the K+-Independent Activity of Crenarchaeota Pyruvate Kinases. (2015) PLoS One. 10, e0129757 Pubmed PLoS One PMC Article

Hernández-Alcántara G, Torres-Larios A, Enríquez-Flores S, García-Torres I, Castillo-Villanueva A, Méndez ST, de la Mora-de la Mora I, Gómez-Manzo S, Torres-Arroyo A, López-Velázquez G, Reyes-Vivas H and Oria-Hernández J. Structural and functional perturbation of Giardia lamblia triosephosphate isomerase by modification of a non-catalytic, non-conserved region. (2013) PLoS One. 8, e69031 Pubmed PLoS One PMC Article

De la Vega-Ruíz G, Domínguez-Ramírez L, Riveros-Rosas H, Guerrero-Mendiola C, Torres-Larios A, Hernández-Alcántara G, García-Trejo JJ and Ramírez-Silva L. New insights on the mechanism of the K(+-) independent activity of crenarchaeota pyruvate kinases. (2015) PLoS One. 10, e0119233 Pubmed PLoS One PMC Article